Description Dissertation title: “Gap junctions in health and disease. Are these good therapeutic targets?” Summary of dissertation topic given by the university: “Gap junctions play an important part in cell signalling in multicellular systems. They consist of membrane channels through which molecules and ions pass directly from cell to cell. The structural proteins of gap junctions are encoded by two gene families, connexins and innexins/pannexins. Dysfunctional gap junctions are implicated in a wide variety of human disorders including peripheral neuropathy, epilepsy, deafness, cataract and skin disorders. This project will review the structure and functions of gap junctions, consider their involvement in one or more disorder, and their potential as therapeutic targets. ” Will need to include an abstract, contents, abbreviations, introduction, critical analysis (data analysis), discussion and reference list section.
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